The Muskitia region in the easternmost part of Honduras is undergoing an unprecedented change in land titling. Indigenous people who have been occupying this area are receiving titles to the land, and at the end of this process, the indigenous territorial space in northeastern Honduras could cover almost 14% of the country. This is the most significant development since the agrarian reform in the second half of the 20th century. This process has a strong political significance and will have wide-ranging implications throughout the country. This Information Brief explores some of these implications, particularly some opportunities and challenges that this process entails for the country’s Indigenous Peoples.